ag8亚游集团官网|平台

刘艳

副教授 硕士生导师

刘  艳   副教授, 硕士生导师

北京市海淀区学院路38号,邮编  100191

Tel: (+8610) 82801508

Email: yanliu@bjmu.edu.cn

 

    1986年在山东大学化学系获得理学学士学位。1989年在山东大学化学系获得理学硕士学位。同年8月到北京医科大学药学院工作。1998-2000年到德国雷根斯堡大学化学与药学系工作与学习。2000年至今,任北京大学ag8亚游集团官网|平台副教授。讲授物理化学、物理药剂学和分散体系的物理化学等本科、硕士和博士研究生课程。担任《化学学报》、《药学学报》、《中国药学杂志》、《中国新药杂志》、Biomaterials、Acta Biomaterialia、Biomacromolecules、Molecular Pharmaceutics、International Journal of Pharmaceutics、Pharmaceutical Research等多个学术期刊的评审。主持或参加的基金项目包括国家自然科学基金、973重大研究计划、国家重大新药创制专项新剂型与新释药系统技术平台等。在国内、外学术期刊上发表论文80余篇。主编教材或专着6部,主译专着1部,参编教材4部。获得国家发明专利9项。主持完成了数个药物制剂的研究开发工作。

 

研究兴趣

物理药剂学。主要涉及以下研究领域

1. 新型纳米载体系统与靶向给药

2. 功能高分子材料与智能释药系统

3. 药物多晶型

 

代表性论文

1.Xiaoyou Qu, Yang Zou, Yuanhang Zhou, Yan Liu*, et al. Self-assembled nanoparticles from vitamin E succinate-based amphiphilic polymers for effective intestinal delivery of paclitaxel and their transcellular transport mechanisms and intracellular trafficking routes. Drug Delivery , 2018, 25(1):210-225.

 

2. Dishi Wang, Yanxia Zhou, Xinru Li, Yan Liu*, et al. Mechanisms of pH-sensitivity and cellular internalization of PEOz-b-PLA micelles with varied hydrophilic/hydrophobic ratios and intracellular trafficking routes and fate of the copolymer. ACS Applied Materials and Interfaces, 2017,9:6916-6930.

3. Ziqi Wang, Xinru Li, Dishi Wang, Yan Liu*, et al. Concurrently suppressing multidrug resistance and metastasis of breast cancer by co-delivery of paclitaxel and honokiol with polymeric micelles.  Acta Biomaterialia , 2017, 62:144-156.

4. Xiaoyou Qu, Yang Zou, Yuanhang Zhou, Yan Liu*, et al. Preparation and characterization of pH-responsive polymeric micelles based on poly(2-ethyl-2-oxazoline)-vitamin E succinate for paclitaxel delivery.  Journal of Chinese Pharmaceutical Sciences . 2017, 26(8): 582-588.

5. Yajie Gao, Yanfang Li, Yushu Li, Yan Liu*, et al. PSMA-mediated endosome escape-accelerating polymeric micelles for targeted therapy ofprostate cancerand the real time tracing of their intracellular trafficking.  Nanoscale , 2015, 7(2):597-612.

6. Jinwen Li, Yanxia Zhou, Chengwei Li, Yan Liu*, et al. Poly(2-ethyl-2-oxazoline)-doxorubicin conjugate-based dual endosomal pH-sensitive micelles with enhanced antitumor efficacy.  Bioconjugate Chemistry , 2015, 26(1):110-119.

7. Yong Zhao, Yanxia Zhou, Dishi Wang, Yan Liu*, et al. pH-responsive polymeric micelles based on poly(2-ethyl-2-oxazoline)-poly(D,L-lactide) for tumor-targeting and controlled delivery of doxorubicin and P-gp inhibitor. Acta Biomaterialia , 2015,17:182-192.

8. Yajie Gao, Chao Zhang, Yanxia Zhou, Yan Liu*, et al. Endosomal pH-responsive polymer-based dual-ligand-modified micellar nanoparticles for tumor targeted delivery and facilitated intracellular releaseof paclitaxel.  Pharmaceutical Research , 2015, 32(8):2649-2662.

9. Lei Zhao, Yanxia Zhou, Yajie Gao, Yan Liu*, et al.Bovine serum albumin nanoparticles for delivery of tacrolimus to reduce its kidney uptake and functional nephrotoxicity.  International Journal of Pharmaceutics , 2015, 483:180-187.

10. Yajie Gao, Yanxia Zhou, Lei Zhao, Yan Liu*, et al. Enhanced antitumor efficacy by cyclic RGDyK-conjugated and paclitaxel-loaded pH-responsive polymeric micelles.  Acta Biomaterialia , 2015, 23:127-135.

11. Wenjing Li, Xinru Li, Yajie Gao, Yan Liu*, et al. The Inhibition Mechanism of P-glycoprotein Mediated Efflux by mPEG-PLA and Influence of PLA Chain Length on P-glycoprotein Inhibition Activity.  Molecular Pharmaceutics, 2014,11:71-80.

12. Chao Fan, Xinru Li, Yanxia Zhou, Yan Liu*, et al. Enhancedtopical delivery of tetrandrine by ethosomes for treatment of arthritis.  Journal of Biomedicine and Biotechnology , 2013, Article ID 161943.

13. Na Li, Xinru Li, Yanxia Zhou, Yan Liu*, et al. The use of polyion complex micelles to enhance the oral delivery of salmon calcitonin and transport mechanism across the intestinal epithelial barrier.  Biomaterials , 2012, 33(34):8881-8892.

14. Guiling Li, Yating Fan, Xinru Li, Yan Liu*, et al. In vitro and in vivo evaluation of a simple microemulsion formulation for propofol.  International Journal of Pharmaceutics , 2012, 425:53–61.

15. Guiling Li, Chao Fan, Xinru Li, Yan Liu*, et al. Preparation and in vitro evaluation of tacrolimus loaded ethosomes.  The Scientific World Journal , 2012, Article ID 874053.

16. Guiling Li, Yating Fan, Chao Fan, Yan Liu*, et al. Tacrolimus-loaded ethosomes: Physicochemical characterization and in vivo evaluation.  European Journal of Pharmaceutics and Biopharmaceutics , 2012, 82:49-57.

17. Xingwei Chen, Xinru Li, Yanxia Zhou, Yan Liu*, et al. Chitosan-based thermosensitive hydrogel as a promising ocular drug delivery system: preparation, characterization and in vivo evaluation.  Journal of Biomaterials Applications , 2012, 27(4): 391-402.

18. Xiaoning Wang, Xinru Li, Yanxia Zhou, Yan Liu*, et al. Synthesis, characterization and biocompatibility of poly(2-ethyl-2-oxazoline)-poly(D,L-lactide)-poly(2-ethyl-2-oxazoline) hydrogels.  Acta Biomaterialia , 2011, 7: 4149-4159.

19. Xinru Li, Yuanting Yue, Yanxia Zhou, Yan Liu*, et al. An oil-free microemulsion for intravenous delivery of diallyl trisulfide: Formulation and evaluation.  International Journal of Pharmaceutics , 2011, 407:158-166.

20. Xinru Li, Yanhui Zhang, Yating Fan, Yan Liu*, et al. Preparation and evaluation of novel mixed micelles as nanocarriers for intravenous delivery of propofol.  Nanoscale Research Letters , 2011, 6:275.

21. Yating Fan, Xinru Li, Yanxia Zhou, Yan Liu*, et al. Improved intestinal delivery of salmon calcitonin by water-in-oil microemulsions.  International   Journal of Pharmaceutics, 2011, 416:323-330.

22. Yanhui Zhang, Xinru Li, Yanxia Zhou, Yan Liu*, et al. Cyclosporine A-loaded poly(ethylene glycol)-b-poly(D,L-lactic acid)  micelles: preparation, in vitro and in vivo characterization and transport mechanism across the intestinal barrier.  Molecular Pharmaceutics , 2010, 7(4):1169-1182.

23. Wang Fei, Li Xinru, Zhou Yanxia, Yan Liu*, et al. Novel nanoscaled polyion complex micelles for targeted delivery of recombinant hirudin to platelets based on cationic copolymer.  Molecular Pharmaceutics , 2010, 7(3):718-726.

24. Xinru Li, Pingzhu Li, Yan Liu*, et al. Novel mixed polymeric micelles for enhancing delivery of anticancer drug and overcoming multidrug resistance in tumor cell lines simultaneously. Pharmaceutical Research , 2010, 27(8):1498-1511.

25. Xinru Li, Xiaoyan Li, Yanxia Zhou, Yan Liu*, et al. Development of patch and spray formulations for enhancing topical delivery of   sinomenine hydrochloride.  Journal of Pharmaceutical Sciences,  2010, 99(4):1790-1799.

26. Yanhui Zhang, Xinru Li, Yanxia Zhou, Yan Liu*, et al. Preparation and evaluation of poly(ethylene glycol)–poly(Lactide) micelles as nanocarriers for oral Deliveryof cyclosporine A.  Nanoscale Resrarch Letters , 2010, 5:917-925.

27. Xinru Li, Quan Yuan, Yanqing Huang, Yan Liu*, et al.Development of silymarin self-microemulsifying drug delivery system with enhanced oral bioavailability.  AAPS PharmSciTech , 2010, 11(2):672-678.

28. Ming Chen, Xin-Ru Li, Yan-Xia Zhou,Yan Liu*, et al. Improved absorption of salmon calcitonin by ultraflexible liposomes  through intranasal delivery.  Peptides , 2009,30:1288-1295.

29. Kewei Yang, Xinru Li, Zhuoli Yang, Yan Liu*, et al. Novel polyion complex micelles for liver-targeted delivery of diammonium glycyrrhizinate: in vitro and in vivo characterization.  Journal of Biomedical Materials Research Part A,  2009, 87(4):140-148.

30. Xinru Li, Yanqing Huang, Xingwei Chen, Yanxia Zhou, Yan Liu*, et al. Self-assembly and characterization of Pluronic P105 micelles for liver-targeted delivery of silybin.  Journal of Drug Targeting , 2009, 17(10):739-750.

31. Xinru Li, Zhuoli Yang, Kewei Yang, Yan Liu*, et al. Self-assembled polymeric micellar nanoparticles as nanocarriers for poorly soluble anticancer drug ethaselen.  Nanoscale Resrarch Letters , 2009, 4:1502-1511.

32. Zhuoli Yang, Xinru Li, Kewei Yang, Yan Liu*. Amphotericin B-loaded poly(ethylene glycol)-poly(lactide) micelles: preparation, freeze-drying and in vitro release.  Journal of Biomedical Materials Research Part  A, 2008, 85(2):539-546.