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李馨儒

副教授 硕士生导师

馨儒  博士,副教授,硕士研究生导师

电话: (10)-82801508

邮箱: ll@bjmu.edu.cn

    1995年在沈阳药科大学药学系获得药物制剂专业学士学位。1998年在沈阳药科大学获得药剂学理学硕士学位。2011年在北京大学药学院获得药剂学在职博士学位。同年8月到北京医科大学药学院工作。主讲物理化学、物理药剂学实验和药用高分子材料学。参加的基金项目包括国家自然科学基金、973重大研究计划、国家重大新药创制专项新剂型与新释药系统技术平台等。在国内、外学术期刊上发表论文20余篇。参编教材或专着2部。申请国家发明专利10项。主持完成了数个药物制剂的研究开发工作。

 

研究方向    药用高分子材料学  物理药剂学

 

研究兴趣

1. 多功能聚合物材料(合成、性质、评价及其应用)

2. 新型靶向给药系统(肿瘤靶向、脑靶向等)

3. 纳米制剂(脂质体、胶束、微乳等)

 

代表性论文

1.Xinru Li, Yanqing Huang, Xingwei Chen, Yanxia Zhou, Yan Liu, et al. Self-assembly and characterization of Pluronic P105 micelles for liver-targeted delivery of silybin. Journal of Drug Targeting, 2009, 17(10):739-750.

2. Xinru Li, Yuanting Yue, Yanxia Zhou, Yan Liu, et al. An oil-free microemulsion for intravenous delivery of diallyl trisulfide: Formulation and evaluation. International Journal of Pharmaceutics, 2011, 407:158-166.      

3. Xinru Li, Yanhui Zhang, Yating Fan, Yan Liu, et al. Preparation and evaluation of novel mixed micelles as nanocarriers for intravenous delivery of propofol. Nanoscale Research Letters, 2011, 6:275.  

4.Xinru Li, Pingzhu Li, Yan Liu, et al. Novel mixed polymeric micelles for enhancing delivery of anticancer drug and overcoming multidrug resistance in tumor cell lines simultaneously. Pharmaceutical Research, 2010, 27(8):1498-1511.   

5. Xinru Li, Xiaoyan Li, Yanxia Zhou, Yan Liu, et al. Development of patch and spray formulations for enhancing topical delivery of  sinomenine hydrochloride. Journal of Pharmaceutical Sciences, 2010, 99(4):1790-1799. 

6.Xinru Li, Quan Yuan, Yanqing Huang, Yanxia Zhou, and Yan Liu. Development of silymarin self-microemulsifying drug delivery system with enhanced oral bioavailability. AAPS PharmSciTech, 2010, 11(2):672-678.

7. Xinru Li, Zhuoli Yang, Kewei Yang, Yan Liu, et al. Self-assembled polymeric micellar nanoparticles as nanocarriers for poorly soluble anticancer drug ethaselen. Nanoscale Resrarch Letters, 2009, 4:1502-1511. 

8. Wang Fei, Xinru Li, Zhou Yanxia, Yan Liu, et al. Novel nanoscaled polyion complex micelles for targeted delivery of recombinant hirudin to platelets based on cationic copolymer. Molecular Pharmaceutics, 2010, 7(3):718-726.

9. Yanhui Zhang,Xinru Li, Yanxia Zhou, Yan Liu, et al. Cyclosporine A-loaded poly(ethylene glycol)-b-poly(D,L-lactic acid)  micelles: preparation, in vitro and in vivo characterization and transport mechanism across the intestinal barrier. Molecular Pharmaceutics, 2010, 7(4):1169-1182. 

10. Ming Chen , Xinru Li, Yan-Xia Zhou, Yan Liu, et al. Improved absorption of salmon calcitonin by ultraflexible liposomes  through intranasal delivery. Peptides, 2009,30:1288-1295.